It may now be possible to associate particular clones to symptoms of the disease and organ involvement while identifying new treatments before they cause irreversible damage. Identifying and isolating the signature of these rogue clones can provide information about whether a drug therapy is working or not.”

“But with our new finding, we have advanced from measuring the level of autoantibody to breaking down their precise clonal components. “Lupus can present in hundreds of different and unpredictable ways, making the diagnosis difficult, particularly when you consider that the methods for measuring anti-dsDNA autoantibodies are decades old and give no information on their molecular composition,” says Professor Gordon Professor Tom Gordon, Head of Immunology at Flinders University says identifying and tracking down the molecular signatures of ‘rogue clones’ could lead to earlier diagnosis and more effective treatments. Symptoms and severity can depend on individual circumstances. The result is an autoimmune attack causing severe fatigue, joint pain, skin rashes and damage to kidneys, lungs, the brain and blood vessels. Normally a healthy immune system helps our body fight off infections, viruses and diseases by identifying and destroying them.īut when a person suffers from Lupus, their immune system cannot tell the difference between foreign invaders and their own healthy tissues. A medical discovery which reveals the structure of ‘rogue clones’ that cause Lupus, could identify early signs of the debilitating autoimmune disease and develop effective treatments.

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